Colón-Emeric is originally from Puerto Rico. His research engages the thought of figures like Thomas Aquinas, John Wesley, and Bartolomé de las Casas with the intent of achieving mestizajes of classical theology, Methodist experience, and Latino history. Colón-Emeric is an ordained elder in the North Carolina Conference; he was founding pastor of Cristo Vive UMC and continues to serve in Hispanic Ministries in Methodist churches in North Carolina.